Whereas PIP4K2A/B positively regulates autophagic flux, PIP4K2C knockdown was shown to reduce the levels of an autophagy cargo protein and mutant huntingtin protein (mHTT) and to positively regulate mTORC115–19 Yet, the biology of PIP4K2C is poorly understood, its role in viral infections remains unexplored, and its therapeutic relevance remains unknown. The gene discussed is PIP4K2C; the disease is viral infectious disease.