Several genes including MAP1LC3B, SQSTM1 and PLEKHM1 demonstrated a pattern wherein expression level was significantly downregulated upon SARS-CoV-2 infection (vs. no infection) in DMSO-treated ALOs and significantly upregulated in response to RMC-113 treatment (Fig. 5m-o, and Supplementary Fig. 8c,d). This evidence concerns the gene MAP1LC3B and infection.