Both DFO and Lip-1 induced degradation of the iron storage protein ferritin and iron regulatory protein 2 (IRP2) in primary human pancreatic ductal adenocarcinoma (PDAC) cells, indicating that upon binding to lysosomal iron, these compounds deplete the available cellular iron pool28, providing a rationale for their toxicity at high concentrations (Fig. 1f). The gene discussed is IREB2; the disease is pancreatic ductal adenocarcinoma.