SND is common in HF and linked to a reduction in functional SAN reserve.30 To address a possible role of caveolae/Cav-3 downregulation in SND in HF, we employed an 8-week post-myocardial infarction mouse model of HF and compared them with age-matched control mice (AMC; Fig. S17). The gene discussed is CAV3; the disease is myocardial infarction.