CAV3 and Sinus bradycardia: These findings hold profound translational significance, as patients with CAV3 variants exhibit sinus bradycardia, elevated heart rhythm lability, and cardiac arrest during sleep.21 Additionally, caveolae disruption and Cav-3 downregulation or malfunction are commonly observed in various pathological conditions, including HF,18 atrial fibrillation,19 and hypertension,20 all of which are associated with SND.