As a control, we crossed the aSMACreERT2 mice with the Rosa26-LSL-tdTomato line (herein referred to as aSMA-tdT mice) and injected PyMT cells into their MFP to confirm the presence of aSMA-tdT+ cells exclusively at the tumor site, but not in the bone (Supp Fig. 3A). The gene discussed is DNTT; the disease is neoplasm.