MAPT and Brain atrophy: Interestingly, a study examined the impact of dietary proteins/Amino LP7 (comprising leucine, phenylalanine, and lysine, along with isoleucine, histidine, valine, and tryptophan) on various components of the disease progression in rTg4510 mice, a mouse model of tauopathy, indicated that Amino LP7 supplementation led to improvements in tau-related brain atrophy, synaptic loss, and microglial activation (Sato et al., 2021).