Atovaquone, used within a stabilizer drug delivery platform composed by protoporphyrin IX nanoparticles, induced M2-type TAMs polarization toward M1-type TAMs, transforming “cold tumor” into “hot tumor” and synergized with anti-PD-L1 immunotherapy in a murine model of colon carcinoma (Feng et al., 2023). The gene discussed is CD274; the disease is neoplasm.