Five-cyano-6-phenylpyrimidin derivatives containing an acylurea moiety demonstrated efficacy in inhibiting P-glycoprotein ABCB1, a leading member of ABC transport proteins found to be widely overexpressed in human solid tumors and hematologic malignancies (Wang et al., 2018a; Wang et al., 2018b). The gene discussed is ABCB1; the disease is hematologic disorder.