Studying one of the most aggressive and resistant cancers, i.e., pancreatic ductal adenocarcinoma, Viale et al. found that a subpopulation of dormant tumor cells responsible for tumor relapse relied on oxidative phosphorylation for survival and had features of cancer stem cells (CD133+CD44high cells with spherogenic and tumorigenic capabilities) (Viale et al., 2014). The gene discussed is PROM1; the disease is neoplasm.