Conversely, it has also been reported that miR-92a-3p inhibits invasion, migration, and proliferation by targeting SOX4 in prostate cancer cell lines (Liao et al., 2020) and by targeting Notch1 in glioma stem cells (Song et al., 2016) and Wilms tumor cells (Zhu et al., 2018), showing that despite the pro-tumoral role that has been generally described for miR-92a-3p, the cell type and experimental approach may be more than relevant in defining the response to this microRNA. The gene discussed is NOTCH1; the disease is central nervous system cancer.