Drugs targeting both ataxia telangiectasia mutated (ATM) and ataxia telangiectasia mutated and Rad3 related (ATR) proteins, involved in DNA damage repair, were administered with ionizing radiation in mouse tumor models and demonstrated increased CD8+ T-cell infiltration through canonical and non-canonical STING activation (Liu C. et al., 2023; Jin et al., 2023). The gene discussed is CD8A; the disease is neoplasm.