A synthetic phosphodiesterase-resistant cGAMP derivative was injected concurrently and 24h after mice received 10 Gy in one fraction, causing an early TNFα dependent response from the tumor microenvironment followed by T-cell mediated tumor regression, with control of distant, non-irradiated tumors (Baird et al., 2016). The gene discussed is TNF; the disease is neoplasm.