The cGas-STING pathway is not only an important cellular defense mechanism against intracellular pathogens, generating pro-inflammatory cytokines in response to pathogen-derived cytosolic double-stranded DNA (dsDNA) (Kato et al., 2017), it is now appreciated for its role in several processes, including senescence, genomic instability, autophagy, and relevant to this review, the immunosurveillance of cancer (Beernaert and Parkes, 2023). Here, CGAS is linked to cancer.