Moreover, the p53 dependence in the host mice that was necessary for the anti-tumor effect in Camphausen et al. is consistent with recent findings that p53 signals for TREX1 degradation, resulting in cytoplasmic dsDNA accumulation, cGAS-STING pathway activation, and ultimately immune-dependent tumor regression (Ghosh et al., 2021; Ghosh et al., 2023). This evidence concerns the gene TREX1 and neoplasm.