Overexpressed LncRNA AK044604 (regulator of insulin sensitivity and autophagy [Risa]) can reduce the levels of downstream autophagy-related proteins (Beclin-1 and LC3B) through the SIRT1/glycogen synthase kinase-3β (GSK-3β) axis in the HG environment, leading to podocyte damage, thereby accelerating the development of DKD (Su PP. This evidence concerns the gene GSK3B and diabetic kidney disease.