SLC9A1 and ischemic stroke: Interestingly, recent studies from our lab showed that pharmacological inhibition of NHE1 with potent HOE642 inhibitor (Cariporide) and Rimeporide improved white matter integrity and cognitive function by reducing reactive astrogliosis in mouse models of VCID and ischemic stroke (Liu et al., 2021; Metwally et al., 2023).