NLRP3 and major depressive disorder: In depression-like mice, after 2–6 weeks of chronic mild stress (CMS), the NLRP3 inflammasome activates microglia, leading to the release of an A1 cocktail l (TNF-α, IL-1α, and C1qA) and upregulation of related A1 astrocyte genes (H2-T23, Serping1, H2-D1, Ugt1a5, Fkbp5, Ligp1, Fbln5, Ggta1, C3, Gbp2, Pmsb8 and Amigo2) (Li S et al., 2022).