In a mouse model of VCID, CCH activates NOD-like receptor family, pyrin domain containing 3 (NLRP3), absent in melanoma 2 (AIM2) inflammasome in reactive astrocytes in white matter tracts in mouse brain, as shown by higher numbers of AIM2 and NLRP3 in GFAP+ cells at 4 weeks after BCAS procedure (Matsuyama et al., 2020; Xu et al., 2023). This evidence concerns the gene NLRP3 and melanoma.