Compared to rs6588147 GG in LEPR gene, we identified a protective role of LEPR rs6588147 GA and GA/AA for the occurrence of NSCLC in two genetic models (GA vs. GG: OR = 0.79, 95% CI = 0.65–0.96, p = 0.019 and AA/GA vs. GG: OR = 0.81, 95% CI = 0.61–0.98, p = 0.032, Table 4). The gene discussed is LEPR; the disease is non-small cell lung carcinoma.