Of note, we also found MAPK is activated by α‐hed, as the phosphorylated forms of ERK, p38, and JNK were all increased, and this effect could be diminished by SEA0400, supporting the presumption that α‐hed targets GPCRs to induce Ca2+ mediated paraptosis‐like cell death in CRC (Figure 7). The gene discussed is MAPK8; the disease is colorectal carcinoma.