70). Both mRNA and protein expression of TRPC6 were found somewhat higher levels in RA-FLSs than in OA-FLSs. Moreover, inhibiting expression of TRPC6 in vitro reduced proliferation of, as well as inflammatory mediator and protease production by, RA-FLSs, attenuates FLS-mediated synovial inflammation and joint destruction in RA (Ref. 71). The gene discussed is TRPC6; the disease is rheumatoid arthritis.