TTR and colon adenocarcinoma: To further assess clinical values of 334 candidate CTS genes, we clustered CRC patients based on their transcriptional expression in cancer and found that CRC patients were clustered into two groups that was determined by the optimal perceptual separation of consensus matrix in TCGA Colon Adenocarcinoma (TCGA-COAD) dataset (Figure 2(a), Supplemental Figure S3), which are significantly associated with overall survival (OS) (Figure 2(b)).