4,417 SNPs corresponding to 936 known human genes, have been identified to be significantly associated with AOM-induced CTS, including the majority of the loci identified in previous studies.9,10 Especially our findings are comparable to a recent study in 40 mouse inbred strains,10 consistent with the report that CC mice captures 90% of genetic variations in laboratory inbred mice.24 The results from the CC mice extend the catalog of CTS genes that can be used to evaluate human CRC susceptibility. Here, TTR is linked to colorectal carcinoma.