Gene set enrichment analysis (GSEA) revealed that the knockout of Duox2 resulted in downregulation of the Wnt/β-Catenin, inflammatory response and interferon-g response pathways and increased activation in reactive oxygen species and oxidative phosphorylation pathways (Figure 7(e,f)), all of which play an important role in both tumor development and gut microbiome composition. The gene discussed is DUOX2; the disease is neoplasm.