Our previous evidence demonstratedthat WEPE has powerful potential for attenuating lipid accumulationand obesity-derived diseases such as nonalcoholic steatohepatitisand cognitive decline through obstacles to MG-induced leptin or insulinresistance.5,6,28,29 Furthermore, we hypothesized that WEPE might contributeto appetite control and intestinal homeostasis maintenance throughthe leptin-regulated gut–brain–liver axis. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.