In addition, we also investigated the regulon activity of renal cancer-related transcription factors between subgroups, which indicated that HNF4A, HNF1A, HNF1B, EPAS1 and ZEB2 were activated in the MOICS1 subgroup, while FOXE1, TBX18, TFE3 and TP53 were activated in the MOICS2 subgroup (Figure 4(e)). This evidence concerns the gene HNF1B and renal carcinoma.