We observed a significant decreased expression of MAP-2 (p = 0.016377), SNAP25 (p = 0.0128) and CAMK2 (p = 0.003930) suggesting that inhibition of Nrgn expression induced by overexpression of the lncRNA caused disruption of synaptodendritic integrity, which is implicated in cognitive decline. The gene discussed is NRGN; the disease is Mental deterioration.