MAPT and Alzheimer disease: There is no need to perform multiple transduction experiments as a stable AD hPSC line can be generated due to the characteristic self-renewal of hPSCs. As expected, our AD CO model showed robust expression of AD pathologies, including Aβ accumulation and tauopathy-paired helical filament (PHF)-tau expression, as well as the formation of NFT-like structures and increased cellular apoptosis.