Proteomics analysis of AZGP1 deficient and over-expressing PCa cell lines confirmed enrichment for pathways related to angiogenesis, including YWHAZ, EPHA2, SERPINE1, PDCD6, MMP9, GPX1, HSPB1, COL18A1, RNH1, and ANXA1. AZGP1 suppresses the growth, migration, and tube formation capacity of HUVEC cells. This evidence concerns the gene MMP9 and posterior cortical atrophy.