Proteomics analysis of AZGP1 deficient and over-expressing PCa cell lines confirmed enrichment for pathways related to angiogenesis, including YWHAZ, EPHA2, SERPINE1, PDCD6, MMP9, GPX1, HSPB1, COL18A1, RNH1, and ANXA1. AZGP1 suppresses the growth, migration, and tube formation capacity of HUVEC cells. Here, EPHA2 is linked to posterior cortical atrophy.