Complementary Western blot and IHC analyses furnished further insight into the anti-inflammatory and anti-pyroptotic effects of circSOD2 knockdown, revealing a decrease in the hepatic expression of IL-1β, IL-18, GSDMD, p-p65, and cleaved caspase-1 in circSOD2-silenced NAFLD models (Fig. 9F, G). Here, IL18 is linked to metabolic dysfunction-associated steatotic liver disease.