In keeping with this, we observed that diabetic mice had progressively increasing circulating levels of the archetypal pro-inflammatory cytokines IL-6, TNF and IL-1β following 10 and 18 weeks of hyperglycemia which were corrected toward non-diabetic levels by hUC-MSC injections, albeit to a lesser extent at 18 weeks. This evidence concerns the gene IL1B and Hyperglycemia.