Liu M. et al. suggested that the transcription factor c-Maf critically regulates human M2 macrophages/monocytes infiltrating the tumor and circulating monocytes from patients with NSCLC, as inhibition of c-Maf partially overcomes resistance to anti-PD-1 therapy in a subcutaneous LLC tumor model [38]. This evidence concerns the gene RPL17 and non-small cell lung carcinoma.