There are three mechanisms underlying iron deficiency in CHF: 1) dietary reduction, gastrointestinal edema, and other factors leading to insufficient iron intake; 2) gastrointestinal bleeding caused by the use of antiplatelet aggregation and antiplatelet drugs, leading to increased iron loss; and 3) increased iron regulatory protein (IRP) expression in CHF patients, causing the body to not release enough iron to meet the needs of the tissue [76]. This evidence concerns the gene WNT2 and congestive heart failure.