CX3CR1+ macrophages displayed the upregulation of pro-inflammatory properties and intense interaction with NR5A1+ tumor cells; C1Q+ macrophages showed increased phagocytosis activity and strong interaction with TBX19+ tumor cells; GPNMB+ macrophage with an intermediate level of angiogenesis and phagocytosis showed preferential interactions with POU1F1+ tumor cells. The gene discussed is GPNMB; the disease is neoplasm.