AKT1 and isolated hemihyperplasia: Furthermore, single-sample Gene Set Enrichment Analysis (ssGSEA) highlighted distinct signaling pathways enriched in the IH group (e.g., NFKB, PI3K-AKT-mTOR, NOTCH, WNT, P53), as well as cellular processes (e.g., EMT, hypoxia, and apoptosis).