A mitochondrial-located lipid metabolic gene 3-hydroxy-3-methylglutaryl-Coa Synthase 2 (HMGCS2) was significantly decreased in all the data sets (Fig. 3A and Fig. S1) and the protein level of HMGCS2 was further confirmed using IHC in IPF lung sections (Fig. 3B) and mice lung fibrosis model (Fig. 4A, B). The gene discussed is HMGCS2; the disease is idiopathic pulmonary fibrosis.