HMGCS2 and pulmonary fibrosis: However, HMGCS2 in popocytes (renal cystic epithelial cells) was associated with mitochondrial damage induced by high fructose intake in mice [47], therefore, the effects of HMGCS2 on AECII mitochondria should be explored in the future since the mitochondria damage of AECIIs is considered involved in the initiation of lung fibrosis.