HMGCS2 and idiopathic pulmonary fibrosis: By analyzing a public single-cell data analyzing platform (http://ipfcellatlas.com/) and another independent GEO lung epithelial single-cell RNAseq data set (GSE132915), we found that HMGCS2 was specifically downregulated in AECIIs in IPF (Fig. S3A-C) and isolated mice AECIIs in Bleomycin group indeed showed significant down-regulation of HMGCS2 (Fig. S3D).