Median values of serum LRG1 and their inter-quartile ranges were 63.2 (42.8–94.2) μg/mL in ccRCC, 23.4 (17.7–29.6) μg/mL in non-ccRCC, and 36.0 (23.7–56.7) μg/mL in patients without cancer, respectively (ccRCC vs. non-ccRCC or patients without cancer: P < 0.001). The gene discussed is LRG1; the disease is nonpapillary renal cell carcinoma.