LRG1 and nonpapillary renal cell carcinoma: Meanwhile, the AUC of serum LRG1 that was used for distinguishing ccRCC from non-ccRCC was 0.91 (0.82–0.96), with the highest sensitivity (0.95) and specificity (0.82) obtained at a cut-off value of 31.2 μg/mL (Fig. 3B).