We found that the fraction of CD8+ T cells out of the isolated PBMCs was higher in patients with MCI-AD, while CD8+ T effector memory cells re-expressing CD45RA (TEMRA) cells, a population with potent pro-inflammatory and cytotoxic effector functions [27], were increased in both patients with MCI-AD and with AD dementia (Fig. 1e,f). Here, CD8A is linked to Alzheimer disease.