CD8A and Alzheimer disease: We believe that future research studies should focus on (1) measuring longitudinal immunological changes over the AD course, (2) investigating if immunological changes can predict disease progression in a preclinical stadium, (3) deciphering which self or non-self-antigens are recognized by the accumulated antigen-experienced CD8+ T cells in AD, and (4) elucidating the role of T and B cells in AD pathology.