SPX and rheumatoid arthritis: To investigate the molecular mechanisms underlying SPX regulation of adipocyte browning, RNA-Seq analysis on fully differentiated adipocytes was performed to investigate the global transcriptome changes induced by SPX treatment, the top three enriched terms in the biological process were ‘Cytokine-cytokine receptor interaction’, ‘Thermogenesis’ and ‘Rheumatoid arthritis’ (Fig. 8A), and KEGG enrichment analysis showed that the JAK/STAT signaling pathway was an important pathway involved in the browning action of SPX (Fig. 8B).