PDE5A and neoplasm: The detailed treatment course of the subcutaneous xenograft tumor model is shown in Fig. 10A. The tumor size, growth rate, and weight of the circPDE5A-NP and PDE5A-500aa-NP treatment groups were significantly smaller than in the control group, while treatment with circPDE5A-Mut-NPs reversed the effects of treatment with circPDE5A-NPs and PDE5A-500aa-NPs (Fig. 10B–D).