CDCA5 and nonpapillary renal cell carcinoma: Sunitinib effectively inhibited the cell proliferation of control 786-O and ACHN cells in MTT assay, while CDCA5 overexpression (OE) dampened this effect (Fig. 3C, D), indicating that overexpression of CDCA5 promotes the chemosensitivity of ccRCC cells to sunitinib.