Development of diastolic dysfunction is multifactorial: triglyceride accumulation increases apoptosis of cardiomyocytes, renin–angiotensin–aldosterone system activation and increased aldosterone concentration contribute to myocardial fibrosis, whilst inflammatory cytokines contribute to fibrosis and increased wall stiffness, all contributing to diastolic dysfunction [2]. Here, REN is linked to Myocardial fibrosis.