Activation of Mas using AVE0991 significantly enhanced the neurobehavioral outcomes, as well as facilitating promoting hematoma absorption, reducing brain edema, inhibiting peripheral neutrophil infiltration, decreasing the secretion of inflammatory factors, attenuating neuron apoptosis, and inducing a switch in microglia/macrophage phenotype from pro-inflammatory to regulatory. This evidence concerns the gene MAS1 and hematoma.