We focused on Lyn, a member of the Src family, since ITGA6 depletion alters Lyn phosphorylation in acute lymphoblastic leukemia (ALL), increasing sensitivity to chemotherapy (Gang et al, 2020) and since Lyn could regulate Snail and Slug protein stability in breast and prostate cancer cells (Thaper et al, 2017). Here, ITGA6 is linked to Familial prostate cancer.