In fact, all three samples with elevated mutation rate, including the two tumors sequenced in this study obtained from heterozygous carriers of POLD1 L474P and D316H, and the adenoma from a POLD1 S478N heterozygote (sequence obtained from Robinson et al. [6]), had copy neutral loss of heterozygosity (cnLOH) of the POLD1 region. The gene discussed is POLD1; the disease is adenoma.