Like classic tumor suppressor genes, inactivation of DNA repair genes usually follows the Knudson’s two-hit hypothesis, which requires inactivation of the two alleles of the gene (e.g. cancer-associated MMR genes, MUTYH, BRCA1 and BRCA2, among others) to disrupt the specific DNA repair mechanism [1, 2]. The gene discussed is MRC1; the disease is neoplasm.