MAPT and Alzheimer disease: To compare the Tau-laden neurofibrillary tangle pathology between 3xTg and Thy1-ApoE4/C/EBPβ mice, we conducted neuroimaging to examine Tau pathology in live animals using 18F-AV1451, as a PET tracer for Tau aggregates, and found the radioactive intensities progressively increased in coronal, transverse and sagittal views in both AD mouse models as compared to control mice.