In this study, we employed the standard clinical diagnostic criteria for AD patients, which include MMSE (Mini-mental Stage Examination, cognitive functions), magnetic resonance imaging (MRI) analysis, cerebro-spinal fluid (CSF) Aβ42/Aβ40 ratio, p-Tau and total Tau levels, and Aβ PET and Tau PET, to fully characterize Thy1-ApoE4/C/EBPβ Tg mice and compare with 3xTg AD mice side-by-side. The gene discussed is APOE; the disease is Alzheimer disease.