To investigate whether the neuronal ApoE4/C/EBPβ double transgenic mice mimic AD patients and display progressive learning and memory defects and act as a sporadic AD mouse model, we compared it with broadly employed genetic AD mouse model 3xTg, a triple-transgenic model harboring human patient-derived mutants PS1 (M146V), APP (Swe) and tau (P301L) transgenes [36]. This evidence concerns the gene APOE and Alzheimer disease.