To compare the Tau-laden neurofibrillary tangle pathology between 3xTg and Thy1-ApoE4/C/EBPβ mice, we conducted neuroimaging to examine Tau pathology in live animals using 18F-AV1451, as a PET tracer for Tau aggregates, and found the radioactive intensities progressively increased in coronal, transverse and sagittal views in both AD mouse models as compared to control mice. Here, APOE is linked to Alzheimer disease.