There was a concordant activation of the DDR pathway as well as WRN protein degradation and p53-target gene modulation, which reached a steady state by day 8 at 60 mg per kg, and some markers such as phosphorylated KAP1 (pKAP1) and pCHK2 decreased over time as tumours regressed (Fig. 4c and Extended Data Fig. 8b). The gene discussed is TP53; the disease is neoplasm.