To address this issue across the single-cell landscape of CD8+ TILs, we performed parallel single-cell RNA sequencing (scRNA-seq) and single-cell TCR sequencing (scTCR-seq) of CD8+ TILs sorted from BRAFV600E tumours at day 11 after tumour transplantation into Cd4crePtger2−/−Ptger4fl/fl mice and Ptger2−/−Ptger4fl/fl mice (as control) (Fig. 2a and Extended Data Fig. 4a). The gene discussed is CD8A; the disease is neoplasm.