Analysis of structural variants (SVs) in more than 1200 cancer samples by whole-genome sequencing revealed hundreds of genes located ≤100 kb of an SV breakpoint with altered expression, most of which were up-regulated, including the cancer-associated genes TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2117. The gene discussed is CD274; the disease is cancer.