To investigate abnormal ANXA2 expression in esophageal cancer, we used The UALCAN (http://ualcan.path.uab.edu) and TIMER2.0 (http://timer.comp-genomics.org/) databases to analyze the expression of ANXA2 in tumor and normal tissues (Fig. 1A, Supplementary Fig. 1A). This evidence concerns the gene ANXA2 and esophageal cancer.