We validated a concordant direction of effect sizes of CTBP1, PPM1G, SEPT2, and KRTCAP3 for gout; SKIV2L for heart failure; and AAK1, MAPKAPK5-AS1, POLA2, RSG1, and WWP2 for hypertension (Table 2). This evidence concerns the gene MAPKAPK5 and Hypertension.