To this end we performed H3K27ac ChIP-seq on the same set of samples as that used for H3K27me3 ChIP-seq, but found no appreciable difference in the average distribution of the mark between EZH2-WT and EZH2-mutant lymphomas, whether assessed over the whole genome or specifically at H3K27ac-enriched regions (Supplementary Fig. 4g). The gene discussed is EZH2; the disease is lymphoma.