Importantly, in vivo experiments using TNBC cells with stable knock-down or overexpression of IDH2 in a lung colonization model showed that IDH2 knock-down led to significantly less and smaller tumor metastatic nodules in the lungs (Fig. 5b and Supplementary Fig. S10b), while overexpression of IDH2 resulted in a major increase in lung metastatic tumor nodules (Fig. 5c and Supplementary Fig. S10c). The gene discussed is IDH2; the disease is neoplasm.