IDH2 and cancer: Since the epithelial-to-mesenchymal transition (EMT) process is closely correlated with cancer cell migration and metastasis34, we analyzed the expression of EMT-related genes in IDH2 knock-down TNBC cell lines, and found that E-cadherin expression was significantly increased, whereas SNAIL expression was substantially decreased in the IDH2 knockdown cell lines (Fig. 5d).