TBK1, OPTN, and ATXN2 variants all cause familial ALS but also glaucoma (Rezaie et al., 2002; Kawase et al., 2012; Minegishi et al., 2013; Bailey et al., 2016; Nguyen et al., 2018). This evidence concerns the gene ATXN2 and amyotrophic lateral sclerosis.