Given that DSF inhibition of GC can be greatly enhanced by copper ion as well as that TH can also form stable complex with copper ion (48), we then assessed the potential effect of copper ion on the antitumor capacity of TH (49) and similarly revealed addition of copper ion markedly enhanced TH inhibition of GC cell growth (Figs. 5M and S5G). This evidence concerns the gene TH and gastric cancer.