This study also noted that LRP1-expressing cells, but not cells deficient in LRP1, promoted cytosolic tau aggregation when incubated with modified tau derived from brain lysates of human AD brain tissue extracts (11) when using HEK293T FRET biosensor cells that stably express the P301S FRET biosensor, a commonly used to assay to detect tau seeding activity (12). This evidence concerns the gene MAPT and Alzheimer disease.