The N1358S mutation was identified once among AD cases in a study that included 15,808 AD cases and 16,097 control subjects from multiple European and American cohorts (40) and from exome sequencing of 14 autosomal dominant early-onset AD cases without any mutations on genes known to be causal for AD (APP, PSEN1, and PSEN2) (14). This evidence concerns the gene PSEN2 and Alzheimer disease.