We conducted experiments in which these cells were transfected with SORL1 and incubated with brain lysate from Braak VI AD patients (Fig. 6A) or with high molecular weight (HMW) fractions obtained following size exclusion chromatography (SEC) isolated from brains of AD patients or healthy age-matched control (Fig. 6B) (8, 9). The gene discussed is SORL1; the disease is Alzheimer disease.