We subcutaneously transplanted mouse pancreatic ductal adenocarcinoma (PDAC) into p16-tdTomato mice (Figure 4A) and found that the size and weight of gWAT were dramatically reduced in cancer-bearing mice (Figure 4B, C), which were not caused by reduced food intake (Supplementary Fig. 9A). The gene discussed is CDKN2A; the disease is pancreatic ductal adenocarcinoma.