These findings fit with previously published data on AE with IgG1 antibodies (e.g., NMDAR-AE)22 and on PNS (e.g., Hu- or Yo-PNS),23 which are not found to be strongly associated with specific HLA genes, in contrast to AE with antibodies of predominantly IgG4 subclass such as LGI1-AE with HLA-DRB1*07:01 and CASPR2-LE with HLA-DRB1*11:01.24−26. This evidence concerns the gene HLA-DRB1 and paraneoplastic neurologic syndrome.