One study found that loss-of-function MASLD genetic risk factors introduced into HepG2 hepatoma cells, which express endogenous PNPLA3-I148M, caused enlarged Golgi cisternae relative to parental cells, but this study did not investigate the effects of PNPLA3-I148M alone on the Golgi (57). This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.