In 2019, to investigate the functions of METTL3 in liver development, liver homeostasis maintenance and liver diseases, and underlying mechanisms, we generated mice with hepatocyte-specific METTL3 knockout (METTL3Δhep) by simultaneously crossing METTL3fl/fl mice (with loxP sites flanking exons 4) with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The Jackson Laboratory. This evidence concerns the gene ALB and liver disorder.