We were surprised to find that hepatocyte-specific METTL3 homozygous knockout by Alb-iCre mice (GPT) resulted in liver injury, acute liver failure (ALF) and then postnatal lethality, whereas hepatocyte-specific METTL3 homozygous deletion by Alb-Cre mice (JAX) led to liver damage, but didn’t cause ALF and postnatal lethality. The gene discussed is ALB; the disease is acute liver failure.