TNF and Insulin resistance: In the first place, both diseases share the expression of a proinflammatory cytokines pathway that includes interleukin-(IL)-6, IL-8, IL-12, and tumor necrosis factor-alpha (TNF-α): the latter is one of the most important cytokines involved in metabolic syndrome, dyslipidemia, and insulin resistance, whereas IL-6, IL-8 and IL-12 also promote metabolic syndrome [21].